Ontology highlight
ABSTRACT:
SUBMITTER: Bauer K
PROVIDER: S-EPMC1175039 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Bauer Kristin K Knipper Annika A Tu-Rapp Hoang H Koczan Dirk D Kreutzer Hans-Jürgen HJ Nizze Horst H Mix Eilhard E Thiesen Hans-Juergen HJ Holmdahl Rikard R Ibrahim Saleh M SM
Arthritis research & therapy 20050520 4
Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial hyperplasia. In this study we examined the role of perforin (pfp), a key molecule of the cytotoxic death pathway that is expressed mainly in CD8+ T cells, for the pathogenesis of CIA ...[more]