Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes.

ABSTRACT: Autistic disorder (AutD) is a complex genetic disease. Available evidence suggests that several genes contribute to the underlying genetic risk for the development of AutD. However, both etiologic heterogeneity and genetic heterogeneity confound the discovery of AutD-susceptibility genes. Chromosome 15q11-q13 has been identified as a strong candidate region on the basis of both the frequent occurrence of chromosomal abnormalities in that region and numerous suggestive linkage and association findings. Ordered-subset analysis (OSA) is a novel statistical method to identify a homogeneous subset of families that contribute to overall linkage at a given chromosomal location and thus to potentially help in the fine mapping and localization of the susceptibility gene within a chromosomal area. F

SUBMITTER: Shao Y 

PROVIDER: S-EPMC1180230 | biostudies-literature | 2003 Mar

REPOSITORIES: biostudies-literature