Significant linkage of Parkinson disease to chromosome 2q36-37.
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ABSTRACT:
SUBMITTER: Pankratz N
PROVIDER: S-EPMC1180337 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Publications
Significant linkage of Parkinson disease to chromosome 2q36-37.
Pankratz Nathan N Nichols William C WC Uniacke Sean K SK Halter Cheryl C Rudolph Alice A Shults Cliff C Conneally P Michael PM Foroud Tatiana T
American journal of human genetics 20030313 4
Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this ...[more]
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