Ontology highlight
ABSTRACT:
SUBMITTER: Vissers LE
PROVIDER: S-EPMC1180392 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Vissers Lisenka E L M LE de Vries Bert B A BB Osoegawa Kazutoyo K Janssen Irene M IM Feuth Ton T Choy Chik On CO Straatman Huub H van der Vliet Walter W Huys Erik H L P G EH van Rijk Anke A Smeets Dominique D van Ravenswaaij-Arts Conny M A CM Knoers Nine V NV van der Burgt Ineke I de Jong Pieter J PJ Brunner Han G HG van Kessel Ad Geurts AG Schoenmakers Eric F P M EF Veltman Joris A JA
American journal of human genetics 20031118 6
Microdeletions and microduplications, not visible by routine chromosome analysis, are a major cause of human malformation and mental retardation. Novel high-resolution, whole-genome technologies can improve the diagnostic detection rate of these small chromosomal abnormalities. Array-based comparative genomic hybridization allows such a high-resolution screening by hybridizing differentially labeled test and reference DNAs to arrays consisting of thousands of genomic clones. In this study, we te ...[more]