Search for haplotype interactions that influence susceptibility to type 1 diabetes, through use of unphased genotype data.

ABSTRACT: Type 1 diabetes is a T-cell-mediated chronic disease characterized by the autoimmune destruction of pancreatic insulin-producing beta cells and complete insulin deficiency. It is the result of a complex interrelation of genetic and environmental factors, most of which have yet to be identified. Simultaneous identification of these genetic factors, through use of unphased genotype data, has received increasing attention in the past few years. Several approaches have been described, such as the modified transmission/disequilibrium test procedure, the conditional extended transmission/disequilibrium test, and the stepwise logistic-regression procedure. These approaches are limited either by being restricted to family data or by ignoring so-called "haplotype interactions" between alleles. To o

SUBMITTER: Zhang J 

PROVIDER: S-EPMC1180402 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature