Ontology highlight
ABSTRACT:
SUBMITTER: Niederkofler V
PROVIDER: S-EPMC1180556 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Niederkofler Vera V Salie Rishard R Arber Silvia S
The Journal of clinical investigation 20050801 8
Iron homeostasis plays a critical role in many physiological processes, notably synthesis of heme proteins. Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin. Human mutations in the glycosylphosphatidylinositol-anchored protein hemojuvelin (HJV; also known as RGMc and HFE2) cause juvenile hemochromatosis, a severe iron overload disease, but the way in which HJV inte ...[more]