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Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences.

ABSTRACT: The now-emerging mitochondrial DNA (mtDNA) population genomics provides information for reconstructing a well-resolved mtDNA phylogeny and for discerning the phylogenetic status of the subcontinentally specific haplogroups. Although several major East Asian mtDNA haplogroups have been identified in studies elsewhere, some of the most basal haplogroups, as well as numerous minor subhaplogroups, were not yet determined or fully characterized. To fill the lacunae, we selected 48 mtDNAs from >2,000 samples across China for complete sequencing that cover virtually all (sub)haplogroups discernible to date in East Asia. This East Asian mtDNA phylogeny can henceforth serve as a solid basis for phylogeographic analyses of mtDNAs, as well as for studies of mitochondrial diseases in East and Southeast Asia.

SUBMITTER: Kong QP

PROVIDER: S-EPMC1180693 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature

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Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences.

Kong Qing-Peng QP Yao Yong-Gang YG Sun Chang C Bandelt Hans-Jürgen HJ Zhu Chun-Ling CL Zhang Ya-Ping YP

American journal of human genetics 20030717 3

The now-emerging mitochondrial DNA (mtDNA) population genomics provides information for reconstructing a well-resolved mtDNA phylogeny and for discerning the phylogenetic status of the subcontinentally specific haplogroups. Although several major East Asian mtDNA haplogroups have been identified in studies elsewhere, some of the most basal haplogroups, as well as numerous minor subhaplogroups, were not yet determined or fully characterized. To fill the lacunae, we selected 48 mtDNAs from >2,000 ...[more]

PMID: 12870132

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