Ontology highlight
ABSTRACT:
SUBMITTER: Corada M
PROVIDER: S-EPMC1180753 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Corada Monica M Chimenti Stefano S Cera Maria Rosaria MR Vinci Maria M Salio Monica M Fiordaliso Fabio F De Angelis Noeleen N Villa Antonello A Bossi Mario M Staszewsky Lidia I LI Vecchi Annunciata A Parazzoli Dario D Motoike Toshiyuki T Latini Roberto R Dejana Elisabetta E
Proceedings of the National Academy of Sciences of the United States of America 20050718 30
Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The defect was not observed in mice with an endothelium-restricted deficiency of the protein but was still detectable in mice transplanted with bone marrow from JAM-A(-/-) donors. Microsco ...[more]