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Social cues shift functional connectivity in the hypothalamus.


ABSTRACT: We determined how social stimuli that vary in behavioral relevance differentially activate functional networks in the frog hypothalamus. As measured by egr-1 mRNA levels, activity in three hypothalamic nuclei varied with acoustic stimulus, and these responses were correlated with egr-1 responses in different auditory regions regardless of stimulus. The correlations among hypothalamic nuclei, however, varied as a function of the behavioral relevance of the stimuli. Thus relevant social cues shift the functional connectivity within the hypothalamus, consistent with principles that underlie the simultaneous processing of sensory information in cognitive tasks.

SUBMITTER: Hoke KL 

PROVIDER: S-EPMC1180772 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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Social cues shift functional connectivity in the hypothalamus.

Hoke Kim L KL   Ryan Michael J MJ   Wilczynski Walter W  

Proceedings of the National Academy of Sciences of the United States of America 20050714 30


We determined how social stimuli that vary in behavioral relevance differentially activate functional networks in the frog hypothalamus. As measured by egr-1 mRNA levels, activity in three hypothalamic nuclei varied with acoustic stimulus, and these responses were correlated with egr-1 responses in different auditory regions regardless of stimulus. The correlations among hypothalamic nuclei, however, varied as a function of the behavioral relevance of the stimuli. Thus relevant social cues shift  ...[more]

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