Ontology highlight
ABSTRACT:
SUBMITTER: Severson W
PROVIDER: S-EPMC1181592 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Severson William W Xu Xiaolin X Kuhn Michaela M Senutovitch Nina N Thokala Mercy M Ferron François F Longhi Sonia S Canard Bruno B Jonsson Colleen B CB
Journal of virology 20050801 15
The nucleocapsid (N) protein of hantavirus encapsidates viral genomic and antigenomic RNAs. Previously, deletion mapping identified a central, conserved region (amino acids 175 to 217) within the Hantaan virus (HTNV) N protein that interacts with a high affinity with these viral RNAs (vRNAs). To further define the boundaries of the RNA binding domain (RBD), several peptides were synthesized and examined for the ability to bind full-length S-segment vRNA. Peptide 195-217 retained 94% of the vRNA ...[more]