Ontology highlight
ABSTRACT:
SUBMITTER: Smith MW
PROVIDER: S-EPMC1181963 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Smith Michael W MW Patterson Nick N Lautenberger James A JA Truelove Ann L AL McDonald Gavin J GJ Waliszewska Alicja A Kessing Bailey D BD Malasky Michael J MJ Scafe Charles C Le Ernest E De Jager Philip L PL Mignault Andre A AA Yi Zeng Z De The Guy G Essex Myron M Sankale Jean-Louis JL Moore Jason H JH Poku Kwabena K Phair John P JP Goedert James J JJ Vlahov David D Williams Scott M SM Tishkoff Sarah A SA Winkler Cheryl A CA De La Vega Francisco M FM Woodage Trevor T Sninsky John J JJ Hafler David A DA Altshuler David D Gilbert Dennis A DA O'Brien Stephen J SJ Reich David D
American journal of human genetics 20040414 5
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and A ...[more]