Unknown

Dataset Information

0

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.


ABSTRACT: Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes. The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a balanced translocation that disrupts DISC1 and DISC2. More recently, DISC1 was linked to schizophrenia, broadly defined, in the general Finnish population, through the undertransmission to affected women of a common haplotype from the region of intron 1/exon 2. We present data from a case-control study of a North American white population, confirming the underrepresentation of a common haplotype of the intron 1/exon 2 region in individuals with schizoaffective disorder. Multiple haplotypes contained within four haplotype blocks extending between exon 1 and exon 9 are associated with schizophrenia, schizoaffective disorder, and bipolar disorder. We also find overrepresentation of the exon 9 missense allele Phe607 in schizoaffective disorder. These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders.

SUBMITTER: Hodgkinson CA 

PROVIDER: S-EPMC1182115 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.

Hodgkinson Colin A CA   Goldman David D   Jaeger Judith J   Persaud Shalini S   Kane John M JM   Lipsky Robert H RH   Malhotra Anil K AK  

American journal of human genetics 20040922 5


Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes. The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a balanced translocation that disrupts DISC1 and DISC2. More recently, DISC1 was linked to schizophrenia, broadly defined, in the general Finnish population, through the undertransmission to affected wom  ...[more]

Similar Datasets

| S-EPMC3401899 | biostudies-literature
| S-EPMC5029760 | biostudies-literature
| S-EPMC9075298 | biostudies-literature
| S-EPMC5399898 | biostudies-literature
| S-EPMC3316587 | biostudies-literature
| S-EPMC8615595 | biostudies-literature
| S-EPMC4019327 | biostudies-literature
| S-EPMC4346799 | biostudies-other
| S-EPMC2696182 | biostudies-literature
| S-EPMC8653908 | biostudies-literature