Ontology highlight
ABSTRACT:
SUBMITTER: Gurkan C
PROVIDER: S-EPMC1182321 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Gurkan Cemal C Lapp Hilmar H Alory Christelle C Su Andrew I AI Hogenesch John B JB Balch William E WE
Molecular biology of the cell 20050608 8
Rab GTPases and SNARE fusion proteins direct cargo trafficking through the exocytic and endocytic pathways of eukaryotic cells. We have used steady state mRNA expression profiling and computational hierarchical clustering methods to generate a global overview of the distribution of Rabs, SNAREs, and coat machinery components, as well as their respective adaptors, effectors, and regulators in 79 human and 61 mouse nonredundant tissues. We now show that this systems biology approach can be used to ...[more]