Ontology highlight
ABSTRACT:
SUBMITTER: Bell JK
PROVIDER: S-EPMC1182468 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Bell Jessica K JK Botos Istvan I Hall Pamela R PR Askins Janine J Shiloach Joseph J Segal David M DM Davies David R DR
Proceedings of the National Academy of Sciences of the United States of America 20050725 31
Innate immunity is the first line of defense against invading pathogens. Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA through their ligand-binding domain that is composed of leucine-rich repeats (LRRs). Ligand binding initiates a signaling cascade that leads to the up-regulation of inflammation mediators. In this study, we have expressed and crystallized the ectodomain (ECD) of human TLR3, whic ...[more]