Ab initio prediction of transcription factor targets using structural knowledge.
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ABSTRACT:
SUBMITTER: Kaplan T
PROVIDER: S-EPMC1183507 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
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Ab initio prediction of transcription factor targets using structural knowledge.
Kaplan Tommy T Friedman Nir N Margalit Hanah H
PLoS computational biology 20050624 1
Current approaches for identification and detection of transcription factor binding sites rely on an extensive set of known target genes. Here we describe a novel structure-based approach applicable to transcription factors with no prior binding data. Our approach combines sequence data and structural information to infer context-specific amino acid-nucleotide recognition preferences. These are used to predict binding sites for novel transcription factors from the same structural family. We demo ...[more]
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