Polysialic acid-induced plasticity reduces neuropathic insult to the central nervous system.
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ABSTRACT:
SUBMITTER: El Maarouf A
PROVIDER: S-EPMC1183577 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
Polysialic acid-induced plasticity reduces neuropathic insult to the central nervous system.
El Maarouf Abderrahman A Kolesnikov Yuri Y Pasternak Gavril G Rutishauser Urs U
Proceedings of the National Academy of Sciences of the United States of America 20050729 32
Under chronic conditions of neuropathic pain, nociceptive C terminals are lost from their target region in spinal lamina II, leading to reduced thermal hyperalgesia. This region of the spinal cord expresses high levels of polysialic acid (PSA), a cell surface carbohydrate known to weaken cell-cell interactions and promote plasticity. Experimental removal of PSA from the spinal cord exacerbates hyperalgesia and results in retention of C terminals, whereas it has no effect on plasticity of touch A ...[more]
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