Ontology highlight
ABSTRACT:
SUBMITTER: Pedeux R
PROVIDER: S-EPMC1190357 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Pedeux Remy R Sengupta Sagar S Shen Jiang Cheng JC Demidov Oleg N ON Saito Shin'ichi S Onogi Hitoshi H Kumamoto Kensuke K Wincovitch Stephen S Garfield Susan H SH McMenamin Mary M Nagashima Makoto M Grossman Steven R SR Appella Ettore E Harris Curtis C CC
Molecular and cellular biology 20050801 15
ING2 is a candidate tumor suppressor gene that can activate p53 by enhancing its acetylation. Here, we demonstrate that ING2 is also involved in p53-mediated replicative senescence. ING2 protein expression increased in late-passage human primary cells, and it colocalizes with serine 15-phosphorylated p53. ING2 and p53 also complexed with the histone acetyltransferase p300. ING2 enhanced the interaction between p53 and p300 and acted as a cofactor for p300-mediated p53 acetylation. The level of I ...[more]