Neoadjuvant Chemoradiotherapy vs Chemoimmunotherapy for Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Importance

The association of neoadjuvant chemoimmunotherapy (NCIT) vs chemoradiotherapy (NCRT) with tumor downstaging and survival in locally advanced esophageal squamous cell carcinoma (ESCC) remains unclear because of limited evidence.

Objective

To compare the associations of NCIT and NCRT with tumor regression and long-term survival in patients with locally advanced ESCC.

Design, setting, and participants

In this comparative effectiveness research study, from January 2016 to March 2023, patients with locally advanced ESCC who underwent esophagectomy following NCRT or NCIT were identified from a prospective database of 8 high-volume esophageal surgery centers in China. Follow-up began on the date of surgery and continued until the last recorded contact or March 202

SUBMITTER: Guo X 

PROVIDER: S-EPMC11923775 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature