Ontology highlight
ABSTRACT:
SUBMITTER: Brown A
PROVIDER: S-EPMC1196334 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Brown Anthony A Wang Lei L Jung Peter P
Molecular biology of the cell 20050706 9
According to the "stop-and-go" hypothesis of slow axonal transport, cytoskeletal and cytosolic proteins are transported along axons at fast rates but the average velocity is slow because the movements are infrequent and bidirectional. To test whether this hypothesis can explain the kinetics of slow axonal transport in vivo, we have developed a stochastic model of neurofilament transport in axons. We propose that neurofilaments move in both anterograde and retrograde directions along cytoskeletal ...[more]