Ontology highlight
ABSTRACT:
SUBMITTER: Cantor RM
PROVIDER: S-EPMC1196405 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Cantor Rita M RM Chen Gary K GK Pajukanta Päivi P Lange Kenneth K
American journal of human genetics 20050118 3
This report describes computer implementation of a scheme for joint linkage and association analysis. The model implemented in the computer package Mendel estimates both recombination and linkage-disequilibrium parameters and conducts likelihood-ratio tests for (1) linkage alone, (2) linkage and association simultaneously, and (3) association in the presence of linkage. Application of the method to data from Finnish pedigrees with familial combined hyperlipidemia illustrates its potential for id ...[more]