Ontology highlight
ABSTRACT:
SUBMITTER: Mesquita B
PROVIDER: S-EPMC1199587 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Mesquita Bárbara B Veiga Isabel I Pereira Deolinda D Tavares Ana A Pinto Isabel M IM Pinto Carla C Teixeira Manuel R MR Castedo Sérgio S
BMC cancer 20050811
<h4>Background</h4>The mechanisms of chemoresistance in ovarian cancer patients remain largely to be elucidated. Paclitaxel/cisplatin combination is the standard chemotherapeutic treatment for this disease, although some patients do not respond to therapy. Our goals were to investigate whether TUBB mutations and mismatch repair defects underlie paclitaxel and cisplatin resistance.<h4>Methods</h4>Thirty-four patients with primary ovarian carcinomas (26 serous and eight clear cell carcinomas) trea ...[more]