Ontology highlight
ABSTRACT:
SUBMITTER: Kiebish MA
PROVIDER: S-EPMC1199588 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Kiebish Michael A MA Seyfried Thomas N TN
BMC cancer 20050816
<h4>Background</h4>Somatic mutations in the mitochondrial genome occur in numerous tumor types including brain tumors. These mutations are generally found in the hypervariable regions I and II of the displacement loop and unlikely alter mitochondrial function. Two hypervariable regions of mononucleotide repeats occur in the mouse mitochondrial genome, i.e., the origin of replication of the light strand (OL) and the Arg tRNA.<h4>Methods</h4>In this study we examined the entire mitochondrial genom ...[more]