Ontology highlight
ABSTRACT:
SUBMITTER: van der Stelt M
PROVIDER: S-EPMC1201361 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
van der Stelt Mario M Trevisani Marcello M Vellani Vittorio V De Petrocellis Luciano L Schiano Moriello Aniello A Campi Barbara B McNaughton Peter P Geppetti Piero P Di Marzo Vincenzo V
The EMBO journal 20050818 17
The endocannabinoid anandamide is able to interact with the transient receptor potential vanilloid 1 (TRPV1) channels at a molecular level. As yet, endogenously produced anandamide has not been shown to activate TRPV1, but this is of importance to understand the physiological function of this interaction. Here, we show that intracellular Ca2+ mobilization via the purinergic receptor agonist ATP, the muscarinic receptor agonist carbachol or the Ca(2+)-ATPase inhibitor thapsigargin leads to format ...[more]