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Biosynthesis of natural flavanones in Saccharomyces cerevisiae.

ABSTRACT: A four-step flavanone biosynthetic pathway was constructed and introduced into Saccharomyces cerevisiae. The recombinant yeast strain was fed with phenylpropanoid acids and produced the flavanones naringenin and pinocembrin 62 and 22 times more efficiently compared to previously reported recombinant prokaryotic strains. Microbial biosynthesis of the flavanone eriodictyol was also achieved.

SUBMITTER: Yan Y 

PROVIDER: S-EPMC1214632 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Biosynthesis of natural flavanones in Saccharomyces cerevisiae.

Yan Yajun Y   Kohli Abhijeet A   Koffas Mattheos A G MA  

Applied and environmental microbiology 20050901 9

A four-step flavanone biosynthetic pathway was constructed and introduced into Saccharomyces cerevisiae. The recombinant yeast strain was fed with phenylpropanoid acids and produced the flavanones naringenin and pinocembrin 62 and 22 times more efficiently compared to previously reported recombinant prokaryotic strains. Microbial biosynthesis of the flavanone eriodictyol was also achieved. ...[more]

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