Ontology highlight
ABSTRACT:
SUBMITTER: Malik HS
PROVIDER: S-EPMC122211 | biostudies-literature | 2002 Feb
REPOSITORIES: biostudies-literature
Malik Harmit S HS Vermaak Danielle D Henikoff Steven S
Proceedings of the National Academy of Sciences of the United States of America 20020122 3
All eukaryotes contain centromere-specific histone H3 variants (CenH3s), which replace H3 in centromeric chromatin. We have previously documented the adaptive evolution of the Drosophila CenH3 (Cid) in comparisons of Drosophila melanogaster and Drosophila simulans, a divergence of approximately 2.5 million years. We have proposed that rapidly changing centromeric DNA may be driving CenH3's altered DNA-binding specificity. Here, we compare Cid sequences from a phylogenetically broader group of Dr ...[more]