Ontology highlight
ABSTRACT:
SUBMITTER: Barbosa JA
PROVIDER: S-EPMC122284 | biostudies-literature | 2002 Feb
REPOSITORIES: biostudies-literature
Barbosa João A R G JA Sivaraman J J Li Yunge Y Larocque Robert R Matte Allan A Schrag Joseph D JD Cygler Miroslaw M
Proceedings of the National Academy of Sciences of the United States of America 20020212 4
The histidine biosynthetic pathway is an ancient one found in bacteria, archaebacteria, fungi, and plants that converts 5-phosphoribosyl 1-pyrophosphate to l-histidine in 10 enzymatic reactions. This pathway provided a paradigm for the operon, transcriptional regulation of gene expression, and feedback inhibition of a pathway. l-histidinol dehydrogenase (HisD, EC ) catalyzes the last two steps in the biosynthesis of l-histidine: sequential NAD-dependent oxidations of l-histidinol to l-histidinal ...[more]