Ontology highlight
ABSTRACT:
SUBMITTER: Tsuda Y
PROVIDER: S-EPMC1223121 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Tsuda Yoko Y Nakatani Fumiki F Hashimoto Keiko K Ikawa Satoshi S Matsuura Chikako C Fukada Takashi T Sugimoto Kenji K Himeno Michio M
The Biochemical journal 20030201 Pt 3
Cry1Aa, an insecticidal protein produced by Bacillus thuringiensis, has been shown to bind to cadherin-like protein, BtR175, in Bombyx mori (silkworm) midgut. We previously reported three variant alleles of BtR175 (BtR175a, b and c). When transiently expressed in COS7 cells, all the three BtR175 variants bound to Cry1Aa. We stably expressed BtR175b in HEK293 cells. These BtR175b-expressing cells swelled and died in the presence of activated Cry1Aa in a dose- and time-dependent manner, showing th ...[more]