Ontology highlight
ABSTRACT:
SUBMITTER: Borrelly GP
PROVIDER: S-EPMC1223992 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Borrelly Gilles P M GP Blindauer Claudia A CA Schmid Ralf R Butler Clive S CS Cooper Chris E CE Harvey Ian I Sadler Peter J PJ Robinson Nigel J NJ
The Biochemical journal 20040301 Pt 2
The thylakoid lumen of the cyanobacterium Synechocystis PCC 6803 is supplied with copper via two copper-transporting ATPases and a metallochaperone intermediary. We show that the copper site of this metallochaperone is unusual and consists of two cysteine residues and a histidine imidazole located on structurally dynamic loops. Substitution of this histidine residue enhances bacterial two-hybrid interaction with the cytosolic copper exporter, but not the copper importer, suggesting that the inte ...[more]