Ontology highlight
ABSTRACT:
SUBMITTER: Mace G
PROVIDER: S-EPMC1224689 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Macé Gaëtane G Miaczynska Marta M Zerial Marino M Nebreda Angel R AR
The EMBO journal 20050901 18
Morphine analgesic properties and side effects such as tolerance are mediated by the mu opioid receptor (MOR) whose endocytosis is considered of primary importance for opioid pharmacological effects. Here, we show that p38 mitogen-activated protein kinase (MAPK) activation is required for MOR endocytosis and sufficient to trigger its constitutive internalization in the absence of agonist. Further studies established a functional link between p38 MAPK and the small GTPase Rab5, a key regulator of ...[more]