Ontology highlight
ABSTRACT:
SUBMITTER: Olson JM
PROVIDER: S-EPMC1226076 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
American journal of human genetics 20010807 4
Although mutations in the amyloid-beta precursor protein (APP) gene are known to confer high risk of Alzheimer disease (AD) to a small percentage of families in which it has early onset, convincing evidence of a major role for the APP locus in late-onset AD has not been forthcoming. In this report, we have used a covariate-based affected-sib-pair linkage method to analyze the chromosome 21 clinical and genetic data obtained on affected sibships by the National Institute of Mental Health Alzheime ...[more]