Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.
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ABSTRACT:
SUBMITTER: Alam NA
PROVIDER: S-EPMC1226106 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
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Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.
Alam N A NA Bevan S S Churchman M M Barclay E E Barker K K Jaeger E E EE Nelson H M HM Healy E E Pembroke A C AC Friedmann P S PS Dalziel K K Calonje E E Anderson J J August P J PJ Davies M G MG Felix R R Munro C S CS Murdoch M M Rendall J J Kennedy S S Leigh I M IM Kelsell D P DP Tomlinson I P IP Houlston R S RS
American journal of human genetics 20010314 5
Dominant transmission of multiple uterine and cutaneous smooth-muscle tumors is seen in the disorder multiple leiomyomatosis (ML). We undertook a genomewide screen of 11 families segregating ML and found evidence for linkage to chromosome 1q42.3-q43 (maximum multipoint LOD score 5.40). Haplotype construction and analysis of recombinations permitted the minimal interval containing the locus, which we have designated "MCUL1," to be refined to an approximately 14-cM region flanked by markers D1S517 ...[more]
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