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Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.

ABSTRACT: The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.

SUBMITTER: Shi H

PROVIDER: S-EPMC1226206 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.

Shi Hong H Dong Yong-Li YL Wen Bo B Xiao Chun-Jie CJ Underhill Peter A PA Shen Pei-Dong PD Chakraborty Ranajit R Jin Li L Su Bing B

American journal of human genetics 20050714 3

The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia ...[more]

PMID: 16080116

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