Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit.
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ABSTRACT:
SUBMITTER: Hallmayer JF
PROVIDER: S-EPMC1226211 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
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Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit.
Hallmayer Joachim F JF Kalaydjieva Luba L Badcock Johanna J Dragovic Milan M Howell Sarah S Michie Patricia T PT Rock Daniel D Vile David D Williams Rachael R Corder Elizabeth H EH Hollingsworth Kate K Jablensky Assen A
American journal of human genetics 20050712 3
A novel phenotyping strategy in schizophrenia, targeting different neurocognitive domains, neurobehavioral features, and selected personality traits, has allowed us to identify a homogeneous familial subtype of the disease, characterized by pervasive neurocognitive deficit. Our genome scan data indicate that this subtype, which accounts for up to 50% of our sample, has a distinct genetic basis and explains linkage to chromosome 6p24 reported previously. If representative of other populations, th ...[more]
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