Dataset Information

Guest-induced organization of an optimal receptor from a dynamic receptor library: spectroscopic screening.

ABSTRACT: Complexation of a cis-protected palladium ion and a family of exo-bidentate and -tridentate ligands results in the formation of an equilibrium mixture of numerous metal-linked receptors that are referred to as a dynamic receptor library. We found that a guest induced the selective formation of the optimal receptor of its own. Screening of the library by using difference NMR facilitates the search for new receptors because in difference NMR only receptors interacting with the guest can be observed. An unpredictable heterotopic receptor was discovered by this screening method. Interestingly, the new receptor thus found was assembled quantitatively only in the presence of its optimal guest.

SUBMITTER: Kubota Y

PROVIDER: S-EPMC122682 | biostudies-literature | 2002 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Guest-induced organization of an optimal receptor from a dynamic receptor library: spectroscopic screening.

Kubota Yasuo Y Sakamoto Shigeru S Yamaguchi Kentaro K Fujita Makoto M

Proceedings of the National Academy of Sciences of the United States of America 20020401 8

Complexation of a cis-protected palladium ion and a family of exo-bidentate and -tridentate ligands results in the formation of an equilibrium mixture of numerous metal-linked receptors that are referred to as a dynamic receptor library. We found that a guest induced the selective formation of the optimal receptor of its own. Screening of the library by using difference NMR facilitates the search for new receptors because in difference NMR only receptors interacting with the guest can be observe ...[more]

PMID: 11959936

Similar Datasets

Project description:In this study, we investigate three oxabicyclic compounds, 3,6-dioxabicyclo[3. 1.0]hexane (C4H6O2, ETHF), 7-oxabicyclo[2.2.1]heptane (C6H10O, 14ECH), and 7-oxabicyclo[4.1.0]heptane (C6H10O, 12ECH) as novel promoters for gas hydrates. According to the outcomes of powder X-ray diffraction (PXRD) and synchrotron high-resolution powder diffraction (HRPD), all CH4 hydrates formed with ETHF, 14ECH, and 12ECH were identified to be sII (Fd-3m) hydrates with corresponding lattice parameters of 17.195, 17.330, and 17.382 Å, respectively. It was also clearly demonstrated that CH4 molecules are accommodated in the sII-S cages through solid-state 13C NMR and Raman spectra. Consequently, we clarified that the three compounds observed are large guest molecules (LGMs) that occupy the sII-L cages. Moreover, the thermodynamic stability of each LGM + CH4 (and N2) hydrate system was remarkably improved compared to that of the simple CH4 (and N2) hydrate. In particular, 14ECH manifested several unique features compared to the other two promoters. First, the 14ECH + CH4 hydrate did not dissociate up to room temperature (298 K), even at a moderate pressure of approximately 60 bar. At a given pressure, 14ECH increased the dissociation temperature of the CH4 hydrate by ~18 K, indicating that its promotion capability is as strong as that of tetrahydrofuran (THF), currently considered to be the most powerful promoter. Second, more interestingly, it was revealed by further PXRD, NMR, and Raman analyses that 14ECH forms a simple sII hydrate in the absence of help gases. According to differential scanning calorimetry (DSC) outcomes, we revealed that the simple 14ECH hydrate dissociates at 270~278 K under ambient pressure. In addition to the thermodynamic stability, we also note that the 14ECH + CH4 hydrate presented a sufficiently high temperature of formation, requiring little additional cooling. Given these promising features, we expect that the 14ECH hydrate system can be adopted to realize hydrate-based technologies. We also believe that the LGMs introduced here have considerable potential to serve as alternates to conventional promoters and that they can be widely utilized in both engineering and scientific research fields.

Dataset Information

Guest-induced organization of an optimal receptor from a dynamic receptor library: spectroscopic screening.

Publications

Guest-induced organization of an optimal receptor from a dynamic receptor library: spectroscopic screening.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets