Altered sexual and social behaviors in trp2 mutant mice.
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ABSTRACT:
SUBMITTER: Leypold BG
PROVIDER: S-EPMC122956 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Publications
Altered sexual and social behaviors in trp2 mutant mice.
Leypold Bradley G BG Yu C Ron CR Leinders-Zufall Trese T Kim Michelle M MM Zufall Frank F Axel Richard R
Proceedings of the National Academy of Sciences of the United States of America 20020423 9
We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the electrophysiological response to pheromones in the VNO, suggesting that trp2 plays a central role in mediating the pheromone response. These mutants therefore afford the opportunity to examine the role of the VNO in the generation of innate sexual and social behaviors in mice. Trp2 mutant males and nur ...[more]
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