Ontology highlight
ABSTRACT:
SUBMITTER: Grosser T
PROVIDER: S-EPMC123082 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Grosser Tilo T Yusuff Shamila S Cheskis Ellina E Pack Michael A MA FitzGerald Garret A GA
Proceedings of the National Academy of Sciences of the United States of America 20020514 12
Study of the cyclooxygenases (COXs) has been limited by the role of COX-2 in murine reproduction and renal organogenesis. We sought to characterize COX expression and function in zebrafish (z). Full-length cDNAs of zCOX-1 and zCOX-2 were cloned and assigned to conserved regions of chromosomes 5 and 2, respectively. The deduced proteins are 67% homologous with their human orthologs. Prostaglandin (PG) E(2) is the predominant zCOX product detected by mass spectrometry. Pharmacological inhibitors d ...[more]