Role of B cells in vaccine-induced immunity against coccidioidomycosis.

ABSTRACT: We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice.

SUBMITTER: Magee DM 

PROVIDER: S-EPMC1230979 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature