Role of B cells in vaccine-induced immunity against coccidioidomycosis.
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ABSTRACT:
SUBMITTER: Magee DM
PROVIDER: S-EPMC1230979 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Publications
Role of B cells in vaccine-induced immunity against coccidioidomycosis.
Magee D Mitchell DM Friedberg Rhonda L RL Woitaske Melanie D MD Johnston Stephen Albert SA Cox Rebecca A RA
Infection and immunity 20051001 10
We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice. ...[more]
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