Ontology highlight
ABSTRACT:
SUBMITTER: Ko HJ
PROVIDER: S-EPMC1231050 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Ko Hyun-Jeong HJ Ko Sung-Youl SY Kim Yeon-Jeong YJ Lee Eun-Gae EG Cho Sang-Nae SN Kang Chang-Yuil CY
Infection and immunity 20050901 9
In spite of its many other benefits, DNA vaccine is limited in its application by its insufficient immunogenicity. One promising approach for enhancing its immunogenicity is to maximize its expression in the immunized host. In the current study, we investigated whether codon optimization of the mycobacterial antigen Ag85B gene could enhance the expression and immunogenicity of the Ag85B DNA vaccine. We generated a synthetic humanized Ag85B (hAg85B) gene in which codon usage was optimized for exp ...[more]