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Horizontally acquired genes for purine salvage in Borrelia spp. causing relapsing fever.

ABSTRACT: Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related Borrelia miyamotoi had purA and purB genes of the purine salvage pathway. These were located among the rRNA genes. Phylogenetic analysis indicated that these genes had a different evolutionary history than those of orthologs in other spirochetes.

SUBMITTER: Barbour AG

PROVIDER: S-EPMC1231056 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Horizontally acquired genes for purine salvage in Borrelia spp. causing relapsing fever.

Barbour Alan G AG Putteet-Driver Adrienne D AD Bunikis Jonas J

Infection and immunity 20050901 9

Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related Borrelia miyamotoi had purA and purB genes of the purine salvage pathway. These were located among the rRNA genes. Phylogenetic analysis indicated that these genes had a different evolutionary history than those of orthologs in other spirochetes. ...[more]

PMID: 16113341

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