Ontology highlight
ABSTRACT:
SUBMITTER: Emberly EG
PROVIDER: S-EPMC123227 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Emberly Eldon G EG Wingreen Ned S NS Tang Chao C
Proceedings of the National Academy of Sciences of the United States of America 20020812 17
A typical protein structure is a compact packing of connected alpha-helices and/or beta-strands. We have developed a method for generating the ensemble of compact structures a given set of helices and strands can form. The method is tested on structures composed of four alpha-helices connected by short turns. All such natural four-helix bundles that are connected by short turns seen in nature are reproduced to closer than 3.6 A per residue within the ensemble. Because structures with no natural ...[more]