Ontology highlight
ABSTRACT:
SUBMITTER: Holash J
PROVIDER: S-EPMC123267 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Holash Jocelyn J Davis Sam S Papadopoulos Nick N Croll Susan D SD Ho Lillian L Russell Michelle M Boland Patricia P Leidich Ray R Hylton Donna D Burova Elena E Ioffe Ella E Huang Tammy T Radziejewski Czeslaw C Bailey Kevin K Fandl James P JP Daly Tom T Wiegand Stanley J SJ Yancopoulos George D GD Rudge John S JS
Proceedings of the National Academy of Sciences of the United States of America 20020812 17
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. Initial attempts to block VEGF by using a humanized monoclonal antibody are beginning to show promise in human cancer patients, underscoring the importance of optimizing VEGF blockade. Previous studies have found that one of the most effective ways to block the VEGF-signaling pathway is to prevent VEG ...[more]