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Failure of cefepime therapy in treatment of Klebsiella pneumoniae bacteremia.


ABSTRACT: A case of failure of cefepime treatment of a bloodstream infection with AmpC-producing Klebsiella pneumoniae is reported. The failure was attributed to extended-spectrum beta-lactamase (ESBL) acquisition by the isolate, possibly during therapy. Problems encountered with ESBL detection in AmpC-producing isolates are discussed.

SUBMITTER: Song W 

PROVIDER: S-EPMC1234124 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature

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Failure of cefepime therapy in treatment of Klebsiella pneumoniae bacteremia.

Song Wonkeun W   Moland Ellen S ES   Hanson Nancy D ND   Lewis James S JS   Jorgensen James H JH   Thomson Kenneth S KS  

Journal of clinical microbiology 20050901 9


A case of failure of cefepime treatment of a bloodstream infection with AmpC-producing Klebsiella pneumoniae is reported. The failure was attributed to extended-spectrum beta-lactamase (ESBL) acquisition by the isolate, possibly during therapy. Problems encountered with ESBL detection in AmpC-producing isolates are discussed. ...[more]

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