Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model.
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ABSTRACT:
SUBMITTER: Satten GA
PROVIDER: S-EPMC1235279 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Publications
Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model.
Satten G A GA Flanders W D WD Yang Q Q
American journal of human genetics 20010119 2
We propose a novel latent-class approach to detect and account for population stratification in a case-control study of association between a candidate gene and a disease. In our approach, population substructure is detected and accounted for using data on additional loci that are in linkage equilibrium within subpopulations but have alleles that vary in frequency between subpopulations. We have tested our approach using simulated data based on allele frequencies in 12 short tandem repeat (STR) ...[more]
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