Random genetic drift determines the level of mutant mtDNA in human primary oocytes.
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ABSTRACT:
SUBMITTER: Brown DT
PROVIDER: S-EPMC1235288 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Publications
Random genetic drift determines the level of mutant mtDNA in human primary oocytes.
Brown D T DT Samuels D C DC Michael E M EM Turnbull D M DM Chinnery P F PF
American journal of human genetics 20001229 2
We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes. ...[more]
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