Ontology highlight
ABSTRACT:
SUBMITTER: Breckenridge DG
PROVIDER: S-EPMC123648 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Breckenridge David G DG Nguyen Mai M Kuppig Stephan S Reth Michael M Shore Gordon C GC
Proceedings of the National Academy of Sciences of the United States of America 20020326 7
BAP31 is an integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Here, we describe the procaspase-8 isoform, procaspase-8L, which is ubiquitously expressed and selectively recruited to the BAP31 complex in response to apoptotic signaling by E1A. Procaspase-8L is characterized by the N-terminal extension (Nex) domain, which extends procaspase-8/a at the N terminus and is required for selective association of procaspase-8L with the BAP31 complex. Gene deletion ident ...[more]