Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt A
PROVIDER: S-EPMC123653 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Schmitt Anja A Nebreda Angel R AR
Proceedings of the National Academy of Sciences of the United States of America 20020319 7
Progesterone induces G2-arrested Xenopus oocytes to develop into fertilizable eggs in a process called meiotic maturation. Protein kinase A (PKA), the cAMP-dependent protein kinase, has long been known to be a potent inhibitor of meiotic maturation, but little information is available on how PKA functions. We have cloned two Xenopus PKA catalytic subunit isoforms, XPKAalpha and XPKAbeta. These proteins are 89% identical and both inhibit progesterone-induced meiotic maturation when overexpressed ...[more]