Ontology highlight
ABSTRACT:
SUBMITTER: Katiyar S
PROVIDER: S-EPMC1237066 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Katiyar Samiksha S Joshi Shivanjali S Lennarz William J WJ
Molecular biology of the cell 20050729 10
The deglycosylating enzyme, peptide:N-glycanase, acts on misfolded N-linked glycoproteins dislocated from the endoplasmic reticulum (ER) to the cytosol. Deglycosylation has been demonstrated to occur at the ER membrane and in the cytosol. However, the mechanism of PNGase association with the ER membrane was unclear, because PNGase lacked the necessary signal to facilitate its incorporation in the ER membrane, nor was it known to bind to an integral ER protein. Using HeLa cells, we have identifie ...[more]