Ontology highlight
ABSTRACT:
SUBMITTER: Plummer KA
PROVIDER: S-EPMC1240114 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Plummer Kelly A KA Carothers James M JM Yoshimura Masahiro M Szostak Jack W JW Verdine Gregory L GL
Nucleic acids research 20050930 17
A particularly challenging problem in chemical biology entails developing systems for modulating the activity of RNA using small molecules. One promising new approach towards this problem exploits the phenomenon of 'surface borrowing,' in which the small molecule is presented to the RNA in complex with a protein, thereby expanding the overall surface area available for interaction with RNA. To extend the utility of surface borrowing to include potential applications in synthetic biology, we set ...[more]