Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann T
PROVIDER: S-EPMC124253 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Hofmann Thomas T Schaefer Michael M Schultz Günter G Gudermann Thomas T
Proceedings of the National Academy of Sciences of the United States of America 20020501 11
Hormones, neurotransmitters, and growth factors give rise to calcium entry via receptor-activated cation channels that are activated downstream of phospholipase C activity. Members of the transient receptor potential channel (TRPC) family have been characterized as molecular substrates mediating receptor-activated cation influx. TRPC channels are assumed to be composed of multiple TRPC proteins. However, the cellular principles governing the assembly of TRPC proteins into homo- or heteromeric io ...[more]