Ontology highlight
ABSTRACT:
SUBMITTER: Marchetti MA
PROVIDER: S-EPMC124255 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Marchetti Maria A MA Kumar Sanjay S Hartsuiker Edgar E Maftahi Mohamed M Carr Antony M AM Freyer Greg A GA Burhans William C WC Huberman Joel A JA
Proceedings of the National Academy of Sciences of the United States of America 20020501 11
The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to DNA damage, is poorly understood. Is DNA damage recognized directly, or indirectly through its effects on replication forks? Is the slowing of S phase in part because of competition between DNA synthesis and recombination/repair processes? The results of our genetic analyses of the intra-S-phase checkpoint in the fission yeast, Schizosaccharomyces pombe, suggest that the slowing of S phase depends weakly on the hel ...[more]